9 Best Terminal Illness Anime & Manga

The community had two big reactions when the anime adaptation Kimi no Suizou wo Tabetai (I Want to Eat Your Pancreas) was announced: this is going to be a really sad anime movie and are other anime or manga like it?

Entertainment about terminal illness is a taboo, largely because it’s something that affects people on a personal level. You run the risk of trivializing an illness if your story is bad, but it can provide a huge emotional punch if done right. These anime, manga, and light novels are good examples of how the medium can handle terminal illness.

Keep in mind that “anime magic” is used at times to prevent a death from terminal illness anime. While the ending may come off as cheesy, the rest of the journey will be a cry fest.

Terminal Illness Anime
Seriously, at least one of these series will make you question your life.

9. Sword Art Online: Mother’s Rosario

Sword Art Online: Mother’s Rosario

Author: Kawahara Reki (Writer) / abec (Illustrator)

Chapters: 12 + Prologue (Finished)

Studio: A-1 Pictures

Episodes: 7 (episodes 18-24 of Sword Art Online II)

Quick Pitch: A side story for the series and the final arc for the Sword Art Online II anime.

Asuna learns of a powerful warrior named Absolute Sword who is challenging players to duels. Any who beats Absolute Sword will receive a powerful award.

All 30 challengers, including Leafa and Kirito, have lost to Absolute Sword. Deciding to challenge them, Asuna is surprised to learn that the real identity of the player is a girl named Yuuki.

8. Plastic Memories

Plastic Memories

Studio: Doga Kobo

Episodes: 13

Quick Pitch: Plastic Memories isn’t a “terminal illness” series in the traditional sense, but the story plays out like one. Isla is a Giftia, which is an android with a predetermined lifespan.

Despite only having 2,000 hours of life yet, she is assigned to be Tsukasa’s partner as he learns the world of Giftia retrieval. Tsukasa isn’t aware of Isla’s lifespan and quickly becomes attached to her.

7. Heaven’s Door

Heaven’s Door 1 9 Best Terminal Illness Anime & Manga

MangakaRanko Hongou

Chapters: 4 (Finished)

Quick Pitch: Harumi has spent most of her life in the hospital due to cancer. Most of the days are mundane, but a new patient named Masato livens things up. Despite the staff’s orders, Masato is a heavy smoker and drinker.

Since he doesn’t have much time to live, he doesn’t care too much for the rules. The two become friends and talk about their terminal prognosis.

6. Looking Up At The Half-Moon (Hanbun no Tsuki ga Noboru Sora)

Looking Up At The Half-Moon

Author: Tsumugu Hashimoto (Writer) / Keiji Yamamoto (Illustrator)

Chapters: 41 (Finished)

Studio: Group TAC

Episodes: 6

Quick Pitch: Yuuichi and Rika are teenagers with that are combating illnesses that force them to stay at a hospital. Yuuichi has hepatitis A and Rika has a weak heart valve.

The two begin to fall in love, but their doctors fear that their budding relationship will interfere with their recovery.

5. Fushigi Yuugi Genbu Kaiden

Fushigi Yuugi Genbu Kaiden

Mangaka: Yuu Watase

Chapters: 40 (Finished)

Quick Pitch: Takiko has lived a tough life: the man she loves is married, her mother is dying of tuberculosis, and her father hasn’t been home in over a year.

When Takiko’s father returns home, his is enthralled in translating an ancient text, which upsets Takiko. She steals the notebook and finds herself taken back to ancient China.

4. Full Moon o Sagashite

Full Moon o Sagashite

Mangaka: Arina Tanemura

Chapters: 35 (Finished)

Studio: Studio Deen

Episodes: 52

Quick Pitch: Mitsuki is a 12-year-old girl with a great singing voice. She dreams of becoming an idol and becoming reunited with her crush, but a throat tumor crushes her dreams.

While Mitsuki can still manage to sing, she needs surgery to remove the tumor, but it will damage her vocal cords. Determined to push through, Mitsuki accidentally overhears two shinigami comment that she only has a year to live if she doesn’t get the surgery.

3. Deep Love: Ayu no Monogatari

Deep Love: Ayu no Monogatari

Mangaka: Yoshi (Writer) / Yuu Yoshii (Illustrator)

Chapters: 8 (Finished)

Quick Pitch: Ayu is a 17-year-old high school student with a cynical outlook on life. She doesn’t believe in love or happiness, and that money is the only thing that matters. This leads Ayu to prostitution, but an encounter with an elderly woman may lead to a new world view.

2. Tokidoki

Tokidoki 1 9 Best Terminal Illness Anime & Manga

Mangaka: Naoshi Komi

Chapters: 1 (Finished)

Quick Pitch: A one-shot manga that follows a brief tale between an ill girl and a healthy boy. Hatsu has a rare heart disease that leaves patients with a shortened lifespan when their heart rate increases.

Hato accidentally discovers Hatsu’s secret when he sees a strange device attached to her chest. While Hatsu tries to live an isolated life, her true desire is to live freely with her short time. Learning this, Hato promises to make whatever time Hatsu has left her greatest.

1. Your Lie in April (Shigatsu wa Kimi no Uso)

Your Lie in April

Mangaka: Naoshi Arakawa

Chapters: 44 (Finished)

Studio: A-1 Pictures

Episodes: 22 + 1 OVA

Quick Pitch: Your Lie in April is currently the most popular “terminal illness” series. It chronicles Kosei’s emotional return to music after meeting Kaori.

Kosei is a genius pianist and Kaori is a freestyle violinist, with the pair making a great duo. Just as Kosei gets reacquainted with his love for music, a personal tragedy strikes.

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About the Author

Garima Singh

Moshi Moshi everyone! I'm Garima, an anime enthusiast with a passion for sharing my love of anime with others. I've watched over 1000 anime, and I'm always on the lookout for new and exciting shows to watch.

I love everything about anime, from the stories and characters to the animation and music. I'm also a big fan of anime culture, and I love to learn about Japanese culture and history through anime.

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